• cerebral cortex
• cerebral hemispheres
• forebrain
• hindbrain
• lobes
• midbrain
• neural tube
• neurons
About two weeks after conception, a fluid-filled cavity called the neural tube
begins to formon the back of the human embryo. This neural tube will sink
under the surface of the skin, and the two major structures of the central
nervous system (CNS) will begin to differentiate. The top part of the tube
will enlarge and become the brain; the bottom part will become the spinal
cord. The cavity will persist through development and become the fluidfilled
central canal of the spinal cord and the four ventricles of the brain.
The ventricles and the central canal contain cerebrospinal fluid, a clear
plasmalike fluid that supports and cushions the brain and also provides nutritive
and eliminative functions for the CNS. At birth the average human
brain weighs approximately 12 ounces (350 grams), a quarter of the size of
the average adult brain, which is about 3 pounds (1,200 to 1,400 grams). Development
of the brain in the first year is rapid, with the brain doubling in
weight in the first six months.
The development of different brain areas depends on intrinsic and extrinsic
factors. Internally, chemicals called neurotrophins promote the survival
of neurons (the basic cells of the nervous system that are specialized to
communicate electrochemically with one another) and help determine
where and when neurons will form connections and become diverse neurological
structures. Externally, diverse experiences enhance the survival of
neurons and play a major role in the degree of development of different
neurological areas. Research has demonstrated that the greater the exposure
a child receives to a particular experience, the greater the development
of the neurological area involved in processing that type of stimulation.
While this phenomenon occurs throughout the life span, the greatest im
pact of environmental stimulation in restructuring and reorganizing the
brain occurs in the earliest years of life.
Experience can alter the shape of the brain, but its basic architecture is
determined before birth. The brain consists of three major subdivisions:
the hindbrain (rhombencephalon, or “parallelogram-brain”), the midbrain
(mesencephalon, or “midbrain”), and the forebrain (prosencephalon, or
“forward brain”). The hindbrain is further subdivided into the myelencephalon
(“marrow-brain”) and the metencephalon (“after-brain”), while
the forebrain is divided into the diencephalon (“between-brain”) and the
telencephalon (“end-brain”). To visualize roughly the locations of these
brain areas in a person, one can hold an arm out, bend the elbow 90 degrees,
and make a fist. If the forearm is the spinal cord, where the wrist enlarges
into the base of the hand corresponds to the hindbrain, with the
metencephalon farther up than the myelencephalon. The palm of the
hand, enclosed by the fingers, would be the midbrain. The fingers would be
analogous to the forebrain, with the topmost surface parts of the fingers being
the telencephalon.
One can take the analogy a step further. If a fist is made with the fingers of
the other hand and placed next to the fist previously made, each fist would
represent the two cerebral hemispheres of the forebrain, with the skin of the
fingers representing the forebrain’s cerebral cortex, the six layers of cells
that cover the two hemispheres. Finally, like close-fitting gloves, the meninges
cover the cortex. The three layers of the meninges play a protective and
nutritive role for the brain.
The more advanced the species, the greater the development of the
forebrain in general and the cortex in particular. The emphasis here is
placed on a neuroanatomical examination of the human brain, beginning
with a look at the hindbrain and progressing to an investigation of the cerebral
cortex. The terms “anterior” (“toward the front”) and “posterior” (“toward
the back”) will be used frequently in describing the location of different
brain structures. Additionally, the words “superior” (“above”) and
“inferior” (“below”) will be used to describe vertical locations.
pact of environmental stimulation in restructuring and reorganizing the
brain occurs in the earliest years of life.
Experience can alter the shape of the brain, but its basic architecture is
determined before birth. The brain consists of three major subdivisions:
the hindbrain (rhombencephalon, or “parallelogram-brain”), the midbrain
(mesencephalon, or “midbrain”), and the forebrain (prosencephalon, or
“forward brain”). The hindbrain is further subdivided into the myelencephalon
(“marrow-brain”) and the metencephalon (“after-brain”), while
the forebrain is divided into the diencephalon (“between-brain”) and the
telencephalon (“end-brain”). To visualize roughly the locations of these
brain areas in a person, one can hold an arm out, bend the elbow 90 degrees,
and make a fist. If the forearm is the spinal cord, where the wrist enlarges
into the base of the hand corresponds to the hindbrain, with the
metencephalon farther up than the myelencephalon. The palm of the
hand, enclosed by the fingers, would be the midbrain. The fingers would be
analogous to the forebrain, with the topmost surface parts of the fingers being
the telencephalon.
One can take the analogy a step further. If a fist is made with the fingers of
the other hand and placed next to the fist previously made, each fist would
represent the two cerebral hemispheres of the forebrain, with the skin of the
fingers representing the forebrain’s cerebral cortex, the six layers of cells
that cover the two hemispheres. Finally, like close-fitting gloves, the meninges
cover the cortex. The three layers of the meninges play a protective and
nutritive role for the brain.
The more advanced the species, the greater the development of the
forebrain in general and the cortex in particular. The emphasis here is
placed on a neuroanatomical examination of the human brain, beginning
with a look at the hindbrain and progressing to an investigation of the cerebral
cortex. The terms “anterior” (“toward the front”) and “posterior” (“toward
the back”) will be used frequently in describing the location of different
brain structures. Additionally, the words “superior” (“above”) and
“inferior” (“below”) will be used to describe vertical locations.